J Clin Outcomes Manage
Recognition and management of bipolar depression
Schroeder E, Gao Y, Roberts J, El-Mallakh RS
Abstract: Objective: To review identification and treatment of bipolar depression. Methods: Literature review. Results: Bipolar depression is a common mood state in patients with both bipolar I and II disorders. Identification of bipolar depression depends on screening for both mania and hypomania. While it seems clear that treatment should generally minimize the use of antidepressants, there is a dearth of alternatives demonstrated to be both effective and safe. Avoidance of agents that increase synaptic serotonin appears to be a reasonable goal. While use of second-generation antipsychotic agents has increased, their utility may be more in reducing associated anxiety. Conclusions: Identification and treatment of bipolar depression remains challenging with an inadequate database to properly guide treatment decisions.
Clinical Review Article
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