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JCOM Abstract


J Clin Outcomes Manage 
2009 Mar ;16(3):115-126
Update on the treatment of acne vulgaris
Lai KW, Mercurio MG

Abstract Objective: To provide an evidence-based review of acne treatments. Methods: Review of the literature. Results: Acne vulgaris is a chronic inflammatory condition affecting 40 to 50 million people in the United States. Current treatments target at least 1 of the known pathophysiologic mechanisms involved in acne development. Combination therapy with a topical retinoid and antimicrobial agent is generally recommended as first-line treatment for most patients. Oral antibiotics are often used for moderate to severe acne, and their combined use with benzoyl peroxide can prevent the development of bacterial resistance. There is also good evidence to suggest that oral contraceptives containing estrogen and a progestin are effective in reducing acne lesions in women. Oral isotretinoin has been shown to be effective in clearing severe nodulocystic acne and inducing remission, although it is unclear whether an association between oral isotretinoin use and suicidal behaviors exists. Lasers, light sources, and photodynamic therapy are effective in the treatment of acne; however, further studies are needed to determine the appropriate duration and light source. Conclusion: Effective treatment for acne is available. Patient responses vary, and often more than 1 mode of therapy may be needed.

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