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JCOM Abstract


J Clin Outcomes Manage 
2006 Jun;13(6):342-356
Long-term treatment complications in HIV disease
Choi EI, Libman H

Program Audience Physicians caring for patients with HIV disease. Educational Needs Addressed Highly active antiretroviral therapy (ART) has resulted in dramatic declines in morbidity and mortality among patients infected with HIV. However, a number of complications are associated with long-term ART, including lipodystrophy syndrome, lactic acidosis/acidemia, peripheral neuropathy, and bone disorders. These complications can have a significant negative impact on the quality of life of HIV-infected patients and may predispose to further comorbidities, such as atherosclerotic disease and premature bone fractures. It is important that clinicians caring for HIV-infected patients be aware of the adverse effects of treatment and management options. In this review, the clinical manifestations, risk factors, and pathophysiology of ART-related toxicity syndromes are explored, with an emphasis on clinical assessment and management. Educational Objectives After participating in this CME activity, physicians should be able to 1. Describe the clinical manifestations and pathogenesis of ART-related complications 2. Discuss the association of ART and risk for cardiovascular disease 3. Describe appropriate screening maneuvers for ART-related complications 4. Understand management approaches for ART-related complications

Case-Based Review, CME

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