J Clin Outcomes Manage
Current treatment strategies for the management of chronic hepatitis B
Wong RJ, Ayoub WS
Abstract Objective: To review current treatment strategies for the management of chronic hepatitis B (CHB). Methods: Review of the literature. Results: There are currently 7 drugs approved by the FDA for the treatment of CHB. Inteferon alfa-2a and peginteferon alfa-2a are injectable immunomodulators, while lamivdine, adefovir, telbivudine, entecavir, and tenofovir are direct-acting oral antiviral agents. The goal of treatment in patients with CHB is to reduce the risk of progressive liver dmage that leads to development of complications such as cirrhosis and hepatocellular carcinoma. The timing of treatment initiation and duration of antiviral therapy varies among society guidelines and incorporates analysis of liver fibrosis in conjunction with the alanine aminotransferase level. Conclusion: Hepatitis B is a chronic disease that requires life-long monitoring.
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