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JCOM Abstract


J Clin Outcomes Manage 
2010 Feb;17(2):69-74
The risk of coronary artery disease in women with a history of low birth weight
Schnatz PF, Kubica LE, Murphy JL, O'Sullivan DM

Abstract Objective:??To examine the association between a woman’s birth weight and future prevalence of coronary artery disease (CAD) and CAD risk factors. Methods: ?Data were collected as part of a longitudinal study in women receiving routine mammography screening.?The sample was 807 women with valid birth weight data. The prevalence of CAD (angina, myocardial infarction, abnormal coronary angiogram, coronary artery bypass graft, or stroke) and selected CAD risk factors (diabetes mellitus, hypertension, hypercholesterolemia) were compared in women with and without self-reported low birth weight (LBW), defined as ? 5.5 lb. Results: There were 98 women, or 12.1%, with LBW. In women with and without LBW, the prevalence of CAD was 4.1% vs. 4.1%; diabetes, 10.2% vs. 5.9%; hypertension, 43.9% vs. 35.0%; hypercholesterolemia, 46.9% vs. 41.3%; breast arterial calcification, 12.9% vs. 14.3%; and ? 1 CAD risk factor, 93.1% vs. 91.8%. None of these differences was statistically significant. Conclusions: The data suggest that CAD and CAD risk factors are not directly affected by a history of LBW. The lack of statistically significant findings for univariate comparisons likely is due to a multifactorial etiology. While these findings do not exclude the possibility of a relationship between CAD, CAD risk factors, and LBW, additional data may help explain the associations seen in prior studies.

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