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JCOM Abstract


J Clin Outcomes Manage 
2007 Feb;14(2):99-101
Tolerability of conversion from Carvedilol to Metoprolol in patients with heart failure
Mellen CK, Rindone JP

Abstract Objective: To ascertain the tolerability and safety of changing carvedilol to metoprolol in patients with heart failure. Design: Observational, retrospective review. Setting: Outpatient clinic. Participants: Patients with diagnosis of heart failure or ejection fraction < 40% who were taking carvedilol for at least 6 months before conversion to metoprolol. Measurements: Blood pressure, heart rate, weight, and percentage of patients requiring urgent care and/or hospitalization for heart failure before and after conversion. Background heart failure drug therapy was recorded before and after conversion. Results: 142 patients were reviewed. There was no statistical difference in any parameter measured. 108 patients had no problem with the conversion, and 4 patients had evidence of worse heart failure after conversion. 30 other patients changed back to carvedilol, 8 cases due to worsening heart failure. Conclusion: The majority of patients with heart failure can be switched from carvedilol to metoprolol without adverse sequelae.

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