J Clin Outcomes Manage
Nocturnal gastroesophageal reflux disease
Fass R, Shapiro M, Moore A
Gastroesophageal reflux disease (GERD) is a chronic disorder and the most common disease that affects the esophagus. Approximately 20% of U.S. adults experience GERD-related symptoms at least once per week, and a considerable percentage of GERD patients experience nighttime symptoms. Nocturnal GERD is an underappreciated clinical problem that impacts sleep, daytime function, and work productivity. Nocturnal gastroesophageal reflux has been demonstrated to be an important underlying mechanism for the development of complicated GERD and extraesophageal manifestations of GERD. Physicians need to be aware of the prevalence and impact of this disabling condition.
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