Turner White CommunicationsAbout TWCSubscribeContact TWCHomeSearch
Hospital PhysicianJCOMSMPBRMsCart
Current Contents
Where We Are Indexed
Past Issue Archives
Clinical Communication
In Review
Editorial Board
Information for Authors
Author Form

Reprints, Permissions, & Copyright
Site Map
BACK ISSUE articles are $15 each.
International credit cards NOT accepted.

JCOM Paid Subscribers
user name:
Forgot password?

JCOM Abstract

J Clin Outcomes Manage 
2013 Aug;20(8):364-376
High-density lipoprotein-targeted therapies: hope or disappointment?
Rocco MB

Abstract Objective: To discuss therapies that have been used to target high-density lipoprotein cholesterol (HDL-C), studies that have examined their effects, and implications for practice. Methods: Review of the literature. Results: Observational studies and monotherapy studies with fibrates and niacin suggest a reduction in cardiovascular disease (CVD) events with interventions that modify HDL-C, particularly in patients with metabolic syndrome. Meta-analyses and trials utilizing surrogate markers of CVD risk further support benefits when these medications are added to statin therapy. However, larger controlled trials have not demonstrated reduction in CVD adverse events when therapies to modulate HDL-C such as fibrates, niacin, or investigational cholesteryl ester transfer protein inhibitors have been added to well-treated individuals on statin therapy. Problems with study design, relatively small HDL-C increases with current therapies, and the selected well-treated populations tested limit applying these results to all patients. Conclusion: Statin therapy remains the primary treatment choice to reduce CVD events and although the hunt for HDL-modulating therapies still goes on, there should be restraint in uniformly raising HDL-C with current therapies. In selected populations inadequately treated to recommend low-density lipoprotein cholesterol or non-HDL-C goals, addition of these therapies may offer further benefit.

Clinical Review Article

Search the Turner White index to find abstracts of articles published in JCOM.

New issues are posted one month following publication of the printed journal.

View past issue archives:    2013    2012    2011    2010    2009    2008    2007
   2006    2005    2004    2003     2002     2001     2000     1999

Hospital Physician     JCOM     Seminars in Medical Practice
Hospital Physician Board Review Manuals
About TWC    Subscribe    Contact TWC    Home    Search   Site Map

Copyright © 2018, Turner White Communications
Updated 1/20/14 • jdw