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JCOM Abstract


J Clin Outcomes Manage 
2012 Aug;19(8):376-383
Diagnosis and management of systemic sclerosis
Derk CT

Abstract Objective: To review the diagnosis and treatment of systemic sclerosis (SSc). Methods: Review of the literature. Results: SSc is a relatively rare disease predominantly seen in women between the ages of 25 and 55 years. SSc can be subclassified into limited and diffuse cutaneous forms based on skin findings and serological markers. The 2 main subtypes typically have differing courses and prognoses. The frequency and diverse nature of disease complications makes systematic assessment and long-term follow-up essential to good management of SSc. While there is no universally acceptable disease-modifying agent for treating SSc, there have been significant advances in the management of affected organ systems. Conclusion: Early recognition, diagnosis, and aggressive management can improve the prognosis of SSc. Lack of a universally acceptable disease-modifying agent for this disease makes treatment challenging.

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