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Clinical Review Quiz

  Multiple Sclerosis: Update on Treatment

Lawrence M. Samkoff, MD

Dr. Samkoff is a former Associate Professor of Clinical Neurology, New York Medical College, Valhalla, NY; a former Associate Chief, Neurology Department, Metropolitan Hospital, New York, NY; a Visiting Associate Professor, Department of Neurology - Rochester General Hospital, University of Rochester School of Medicine and Dentistry, Rochester, NY; and an Attending Neurologist, Rochester Multiple Sclerosis Clinic, Rochester, NY.

The questions below are based on the March 2002 cover article, “Multiple Sclerosis: Update on Treatment.”

Choose the single best answer for each question.

1. Which of the following is the most common initial course of multiple sclerosis (MS)?
  1. Primary progressive
  2. Progressive-relapsing
  3. Relapsing-remitting
  4. Secondary progressive
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2. Which of the following neurologic syndromes is rarely associated with MS?

  1. Aphasia
  2. Dementia
  3. Optic neuritis
  4. Transverse myelitis
  5. Trigeminal neuralgia
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3. Which of the following is the most sensitive diagnostic test for detecting MS?

  1. Computed tomography scan of the head
  2. Electroencephalography
  3. Immunoelectrophoresis of cerebrospinal fluid to detect oligoclonal bands
  4. Magnetic resonance imaging of the brain
  5. Measurement of somatosensory evoked potentials
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4. The major benefit of administering interferon beta or glatiramer acetate in the treatment of MS is a reduction in which of the following variables?
  1. Cognitive impairment
  2. Depression
  3. Long-term disability
  4. Pain
  5. Relapse rate
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5. Use of which of the following disease-modifying agents is associated with a syndrome characterized by chest discomfort, palpitations, and flushing?

  1. Glatiramer acetate
  2. Interferon beta-1a
  3. Interferon beta-1b
  4. Methylprednisolone
  5. Mitoxantrone
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