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Clinical Review Quiz

Pharmacologic Therapy for Secondary Stroke Prevention

Kiwon Lee, MD

Dr. Lee is an assistant professor of neurology and neurosurgery, Division of Stroke and Critical Care, Columbia University College of Physicians and Surgeons, New York, NY.



The questions below are based on the article
“Update on Pharmacologic Therapy for Secondary Stroke Prevention”.


Choose the single best answer for each question.


1. What is the estimated risk of stroke in the first month following a transient ischemic attack (TIA)?
  1. 1%
  2. 8%
  3. 11.5%
  4. 18.3%
  5. 21%
Click here to compare your answer.


2. What is the estimated risk of recurrent stroke in the first month following an initial stroke?

  1. 2% to 5%
  2. 6% to 15%
  3. 15% to 18%
  4. 18% to 20%
  5. 20% to 22%
Click here to compare your answer.


3. According to the meta-analysis of 21 trials that evaluated antiplatelet therapy for secondary stroke prevention, what is the percent reduction in fatal stroke for the antiplatelet group compared with the placebo group?

  1. 5%
  2. 7%
  3. 16%
  4. 20%
  5. 35%
Click here to compare your answer.


4. Which of the following statements is correct regarding statin therapy and stroke?

  1. Randomized, controlled trials show that statin therapy reduces the rate of heart attack but not stroke
  2. Randomized, controlled trials show that statin therapy reduces the rate of heart attack and stroke for patients with low-density lipoprotein levels greater than 200 mg/dL but not for those with levels less than 200 mg/dL
  3. Randomized, controlled trials show superior protection against heart attack and stroke depending on individual statin therapy
  4. Randomized, controlled trials show that statin therapy reduces the rate of heart attack and stroke independent of cholesterol levels and individual statin drug
Click here to compare your answer .


5. What is the conclusion of the CHARISMA and ESPRIT studies regarding dual antiplatelet therapy (ie, clopidogrel plus aspirin) compared with single antiplatelet therapy for secondary stroke prevention?

  1. Dual antiplatelet therapy further reduces the rate of recurrent stroke
  2. Dual antiplatelet therapy does not further reduce the rate of recurrent stroke, but the side effect profile is the same compared with the single antiplatelet therapy
  3. Dual antiplatelet therapy does not further reduce the rate of recurrent stroke and increases the risk of hemorrhage
  4. Dual antiplatelet therapy further reduces the rate of recurrent stroke for embolic strokes
  5. Dual antiplatelet therapy reduces the rate of stroke more effectively than carotid endarterectomy for patients with symptomatic carotid artery stenosis
Click here to compare your answer.


6. Which of the following patients should receive warfarin therapy instead of antiplatelet therapy?

  1. A 50-year-old man with a history of atrial fibrillation who has suffered a first TIA
  2. A 50-year-old man with a history of carotid artery stenosis who has suffered a first TIA with the degree of carotid artery stenosis estimated to be 55%
  3. A 50-year-old man with a history of hypertension who has suffered a first lacunar stroke
  4. A 50-year-old man with a history of hypertension who has suffered a first TIA with negative embolic stroke work-up
  5. A 50-year-old man with a history of poorly controlled hypertension who has suffered a first lacunar stroke
Click here to compare your answer.


 

Click here to read more about the Update on Pharmacologic Therapy for Secondary Stroke Prevention
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Clinical Review Quiz Archive



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