Part 1: Ischemic Stroke: Pathophysiology and Principles of Localization
Matthew Brandon Maas, MD, and Joseph E. Safdieh, MD
Dr. Maas is a fellow in Stroke and Neurocritical Care, Harvard Medical School, Departments of Neurology, Massachusetts General and Brigham and Womens Hospitals, Boston, MA. Dr. Safdieh is an assistant professor of neurology, Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, NY.
Vasospasm and ischemic stroke are frequent complications of aneurysmal subarachnoid hemorrhage (SAH). Nimodipine, a calcium channel antagonist, has been shown to improve outcomes when administered soon after diagnosis of SAH. What is the most likely mechanism?