Part 1: Autoimmune Hemolytic Anemia
Thomas G. DeLoughery, MD
Professor of Medicine, Pathology, and Pediatrics, Division of Hematology/Medical Oncology,
Departments of Medicine and Pediatrics, and Division of Laboratory Medicine, Department of
Pathology, Oregon Health Sciences University, Portland, OR
You are asked to consult on a 46-year-old man with “bicytopenia.” Review of the patient’s laboratory test results shows his platelet count is only 5000/μL. The hematocrit is 20% with a corrected reticulocyte count of 10%, and the LDH concentration is elevated 3 times the upper limit of normal. Examination reveals a large spleen and shotty nodes. After 1 week of prednisone therapy at 1 mg/kg daily, there is a rise in both the hematocrit and platelet count. What is the most likely underlying disorder in this patient?