Part 2: Chronic Lymphocytic Leukemia

Kami J. Maddocks, MD

Assistant professor of Internal Medicine, Division of Hematology, The Ohio State University, Columbus, OH

Samantha M. Jaglowski, MD

Assistant professor of Internal Medicine, Division of Hematology, The Ohio State University, Columbus, OH

Question 3

Which of the following is TRUE regarding cytogenetics in CLL?

  •   Trisomy 12 is the most common abnormality seen in fluorescent in-situ
    hybridization (FISH)
  •   Deletion of 11q23 is associated with MYC overexpression
  •   Patients presenting with somatic hypermutation of the immunoglobulin
    heavy chain variable region (IGVH) gene usually have a more aggressive
    disease course
  •   Patients with deletion of 17p13 typically have aggressive disease with a
    median survival of 32 months beyond diagnosis

Updated 08/17/2012 • jdw | Copyright ©2013 Turner White Communications