Part 2: Multiple Myeloma

Todd Zimmerman, MD

Dr. Zimmerman is an associate professor of medicine, Section of Hematology/Oncology, University of Chicago, Chicago, IL.

Question 2

A 64-year-old man presents with newly diagnosed International Staging System stage III IgG/lambda multiple myeloma with a monoclonal protein measuring 5.2 g/dL. He has a history of chronic kidney disease and a long-standing history of hypertension. Serum creatinine has increased from a baseline level of 1.8 mg/dL to 2.4 mg/dL. He has asymptomatic lytic bone disease. Metaphase cytogenetic testing shows deletion of chromosome 13. What is the most appropriate therapy for this patient?

  •  Bortezomib and dexamethasone
  •  Lenalidomide and high-dose dexamethasone
  •  Oral melphalan, prednisone, and thalidomide
  •  Pulse high-dose dexamethasone

Updated 7/7/2009 • nvf | Copyright ©2010 Turner White Communications