Disseminated Intravascular Coagulation

Thomas G. DeLoughery, MD, MACP, FAWM

Professor of Medicine, Oregon Health & Science University, Portland, OR

Question 6

Given that the underlying mechanism of disseminated intravascular coagulation (DIC) is inappropriate activation of thrombin, treatment with an anticoagulant is appealing. However, antithrombin therapy should be strongly considered in only one of the following situations; which situation?

  •   A 6-year-old child with E. coli sepsis
  •   A 23-year-old woman with sudden shortness of breath and DIC after delivery
  •   A 47-year-old man with leg trauma receiving massive transfusion
  •   A 65-year-old man with lung cancer and a new femoral vein thrombosis
  •   A 78-year-old woman bitten by a rattlesnake on a nature walk

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